Messengers mediating information between cells or affecting their activities are so-called cytokines. Cytokines are critical in the pathogenetic process of rheumatoid arthritis, particularly tumour-necrosis-factor (TNF)-\u03b1, interleukin (IL)-1 and IL-6. Biologic disease modifying antirheumatic drugs (bDMARDs) inhibit these messengers and thereby influence the disease course.<\/p>\n
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TNF-\u03b1 inhibiting biologic DMARDs: Benepali\u00ae (etanercept), Cimzia\u00ae (certolizumab pegol), Enbrel\u00ae (etanercept), Erelzi\u00ae (etanercept), Flixabi\u00ae (infliximab), Humira\u00ae (adalimumab), Inflectra\u00ae (infliximab), Remicade\u00ae (infliximab), Remsima\u00ae (infliximab), Simponi\u00ae (golimumab)<\/p>\n
IL-1 inhibiting biologic DMARDs: Kineret\u00ae (anakinra)<\/p>\n
IL-6 inhibiting biologic DMARDs: Kevzara\u00ae (sarilumab), RoACTEMRA\u00ae (tocilizumab)<\/p>\n
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Further essential players in the rheumatic inflammatory cascade are B and T lymphocytes. Activity of these cells can be also blocked by biologic DMARDs.<\/p>\n
B cell inhibiting biologic DMARD: Rixathon\u00ae (rituximab), MabThera\u00ae (rituximab)<\/p>\n
T cell inhibiting biologic DMARD: Orencia\u00ae (abatacept)<\/p>\n
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The targeted synthetic disease modifying antirheumatic drugs (tsDMARDs) inhibit the activity of Januskinase enzymes.<\/p>\n
Januskinase inhibitors: Olumiant\u00ae (baricitinib), Xeljanz\u00ae (tofacitinib)<\/p>\n
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Please find further information on the modes of action and the use of DMARDs on the websites of the German Society of Rheumatology (www.dgrh.de<\/a>), of the Competence Network Rheumatology (www.rheumanet.org<\/a>) or on\u00a0www.rheuma-online.de<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":" Messengers mediating information between cells or affecting their activities are so-called cytokines. Cytokines are critical in the pathogenetic process of … mehr<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":405,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_crdt_document":"","generate_page_header":"","footnotes":""},"class_list":{"0":"post-409","1":"page","2":"type-page","3":"status-publish","5":"infinite-scroll-item"},"_links":{"self":[{"href":"https:\/\/biologika-register.de\/en\/wp-json\/wp\/v2\/pages\/409","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biologika-register.de\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/biologika-register.de\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/biologika-register.de\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biologika-register.de\/en\/wp-json\/wp\/v2\/comments?post=409"}],"version-history":[{"count":1,"href":"https:\/\/biologika-register.de\/en\/wp-json\/wp\/v2\/pages\/409\/revisions"}],"predecessor-version":[{"id":410,"href":"https:\/\/biologika-register.de\/en\/wp-json\/wp\/v2\/pages\/409\/revisions\/410"}],"up":[{"embeddable":true,"href":"https:\/\/biologika-register.de\/en\/wp-json\/wp\/v2\/pages\/405"}],"wp:attachment":[{"href":"https:\/\/biologika-register.de\/en\/wp-json\/wp\/v2\/media?parent=409"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}